I made that trip last November on a friend's a 43 foot trawler. The ICW in S.C. and Ga is tortuous but as Rudy says it can be done., obviously. @We went aground hard in Ga and had to be towed. Don't slavishly follow the magenta line; it hasn't been updated in years. Also get Boat US unlimited towing insurance. Our tow was over 2k because of the distance the boat had to come. The actual tow was maybe 10 minutes. If you are using a chart plotter, I strongly recommend that you review the day's run in advance. Take notes. Following the channel around sharp turns can be tricky. Don't on't be in a hurry. Stop if your are getting tired or are running out of light. Finally, if you are going to outside research the inlets in advance. If you have run an inlet before read up on it. My friend almost lost his boat after I had departed coming into Jupiter.